Chronic prenatal hypoxia impairs cochlear development, a mechanism involving connexin26 expression and promoter methylation

Chronic prenatal hypoxia impairs cochlear development, a mechanism involving connexin26 expression and promoter methylation

Chronic prenatal hypoxia is a damaging to fetal development and may have various consequences, including hearing loss. Connexin 26 (Cx26) is one of the major protein subunits required for gap junction formation, and has an important role in maintaining homeostasis in the cochlea and normal hearing. Cx26 mutation and expression abnormality are closely associated with inherited nonsyndromic deafn...

Promoter Methylation and Gene Expression in Human CD34+ Stem Cells Derived Erythroid Lineage by MicroRNA

Background: Stem Cell differentiation is a process composed of vast variety of factors which are controlled by a network of certain mechanisms. This study aims to determine the possible role of DNA methylation, a potent regulator of VHL, ECAD and RUNX3 genes during Erythroid differentiation driven by miR-451. Materials and Methods: To determine the methylation status of promoters and the e...

Prenatal Caffeine Exposure Impairs Pregnancy in Rats

Background In recent years, concerns have been raised about human reproductive disorders. Caffeine consumption is increasing by the world’s population and there is a relationship between caffeine intake and adverse reproductive outcomes. The aim of this study was to evaluate the effects of caffeine on implantation sites, number of live births, birth weight, crown-rump length (CRL) and abnormali...

Prenatal hypoxia impairs the early postnatal development of the carotid chemoafferent pathway

The Impression of Histone Modification and DNA Methylation in Gastric Cancer Development: Molecular Mechanism Approach

The epigenetic alterations like histone modifications , DNA methylation and others remarkable categories  including nucleosome remodeling and RNA mediated targeting have been strongly investigated  recently .In this way , beside the notable importance of DNA methylation ,the histone modifications are the most important issues in the  tumorogenesis and cancer progression. Moreover...